Methylation the addition of a methyl group (CH3 one carbon attached to three hydrogens) to another molecule is an essential and vital biochemical process in the body involved in multiple biochemical pathways involving neurotransmitters, detoxification, cardiovascular health, eye health, muscle health, bone health, and redox balance. A number of specific nutrients are necessary for the process of methylation to occur normally.*
Methylation is essential to help maintain a normal level of homocysteine.* A deficiency in homocysteine-metabolizing cofactors is commonly seen in the elderly, resulting in an increase in homocysteine levels with advancing age. An elevated homocysteine level associated with aging, as well as low levels of folic acid and vitamins B6 and B12, often results in the decreased methylation of numerous substances, such as DNA and proteins, which in turn decreases the integrity of vascular structures and neurons.* Providing nutritional cofactors for homocysteine metabolism also provides support for a healthy brain.*
A number of biochemical imbalances that raise the level of homocysteine can be addressed by supplementing with appropriate nutrient cofactors. For example, folic acid (as L-5-methyltetrahydrofolate), vitamin B12 (as methylcobalamin), and betaine (trimethylglycine) help recycle homocysteine to the amino acid methionine, while the recycling of homocysteine into the beneficial amino acids cysteine and taurine is facilitated by pyridoxal 5'-phosphate (the active form of vitamin B6).* Studies have shown these nutrients help maintain a normal level of homocysteine in the blood.*
Because homocysteine levels can be higher in individuals in which the enzymatic reaction that converts folic acid to the active methyl donor L-5-methyltetrahydrofolate (5-MTHF) does not function properly, Methyl-Guard contains 400 mcg of active 5-MTHF per capsule.*
ALLERGY WARNING:This product is contraindicated in an individual with a history of hypersensitivity to any of its ingredients.
PREGNANCY: If pregnant, consult your health professional before using this product.
INTERACTIONS: 5-methyltetrahydrofolate (5-MTHF) supplementation is not recommended concurrent with methotrexate cancer therapy, as it can interfere with methotrexate's anti-neoplastic activity; however, this folate source has not been shown to interfere with the anti-inflammatory activity of methotrexate. An individual taking methotrexate for psoriasis or rheumatoid arthritis can safely take a supplement containing folate.
Corn Free,Dairy/Milk/Casein Free,Egg Free,Lactose Free,Paraben Free,Preservative Free,Salt Free,Shellfish Free,Soy Free,Sugar Free,Wheat/Gluten Free,Yeast Free
|Betaine Anhydrous (Trimethylglycine)||1.8g|
|Folate (L-5-MTHF)||2mg DFE|
|Vitamin B12 (Methylcobalamin)||1.2mg|
|Vitamin B6 (Pyridoxal 5'-Phosphate)||20.4mg|
|Other Ingredients: Calcium (Citrate), Calcium Laurate, Hypromellose Capsule, Silicon Dioxide|